| T cell distribution is different in follicle-associated epithelium of human Peyer's patches and villous epithelium. | |
| | |
MedLine Citation:
|
PMID: 2975975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Immunohistochemical analyses performed on specimens of normal human ileum showed a significantly raised number of T cells in the follicle-associated epithelium (FAE) of Peyer's patches compared with the epithelium of distant villi. The T cells tended to be clustered in all layers of the FAE and were significantly more numerous adjacent to interruptions of the brush border (revealed by lack of staining for alkaline phosphatase). Such interruptions were taken to indicate 'membrane' (M) cells. Our findings therefore suggested a spatial relationship between M cells and the aggregation of T cells. The ratio of CD4+ to CD8+ T cells (approximately 4:10) was significantly higher in the FAE than in the villous epithelium (approximately 0.6:10). This suggested that the FAE may be involved to a greater extent in induction of 'helper' T cell functions, perhaps depending on luminal antigens transported by M cells, whereas the villous epithelium may be more involved in stimulation of 'suppressor' T cell functions as indicated by recent studies in vitro. |
| | |
Authors:
|
K Bjerke; P Brandtzaeg; O Fausa |
Related Documents
:
|
12517945 - Microbial colonization drives lymphocyte accumulation and differentiation in the follic... 2670635 - Regulation of tropomyosin expression in the maturing ovary and in primary granulosa cel... 3113435 - Effects of bovine inhibin, transforming growth factor-beta and bovine activin-a on gran... 12108515 - Estradiol and luteinizing hormone regulation of insulin-like growth factor binding prot... 7809385 - Polarized release of lipid mediators derived from phospholipase a2 activity in a human ... 11832345 - Traction fields, moments, and strain energy that cells exert on their surroundings. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 74 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1988 Nov |
Date Detail:
|
Created Date: 1989-03-29 Completed Date: 1989-03-29 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 270-5 Citation Subset: IM |
Affiliation:
|
Medical Department A, University of Oslo, National Hospital, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkaline Phosphatase
/
analysis Antigens, Differentiation, T-Lymphocyte / analysis Fluorescent Antibody Technique Humans Ileum / immunology* Intestinal Mucosa / immunology Leukocyte Count Microvilli / enzymology, immunology Peyer's Patches / immunology* T-Lymphocytes / immunology* T-Lymphocytes, Helper-Inducer / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Differentiation, T-Lymphocyte; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum suppressive activity of HIV seropositive patients.
Next Document: Follow-up of prematurely born infants.