Document Detail


T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis.
MedLine Citation:
PMID:  23199324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma leptin in HT patients and the CD4(+) T cell-derived leptin from HT patients was stronger than that from healthy controls. In HT patients, there are no statistically significant correlations between plasma leptin concentrations and the percentage of Th17 cells or the level of retinoic acid-related orphan receptor γt (RORγt), but strong positive correlations were observed between CD4(+) T cell-derived leptin and the percentage of Th17 cells or the level of RORγt mRNA, and additionally significantly up-regulated leptin, interleukin (IL)17 and RORγt mRNA levels in the thyroid tissue. Furthermore, neutralization of leptin decreases the frequency of Th17 cells in vitro. Current study has revealed an increased leptin involvment in Hashimoto's thyroiditis associated with an increased number of Th17 cells.
Authors:
S Wang; S E Baidoo; Y Liu; C Zhu; J Tian; J Ma; J Tong; J Chen; X Tang; H Xu; L Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / blood,  immunology
CD4-Positive T-Lymphocytes / immunology,  metabolism
Female
Hashimoto Disease / blood,  immunology,  metabolism*
Humans
Interleukin-17 / biosynthesis,  immunology
Leptin / blood*
Leukocytes, Mononuclear / immunology
Middle Aged
Nuclear Receptor Subfamily 1, Group F, Member 3 / biosynthesis,  immunology
Th17 Cells / immunology*
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Interleukin-17; 0/Leptin; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 06LU7C9H1V/Triiodothyronine; Q51BO43MG4/Thyroxine
Comments/Corrections

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