| T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis. | |
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MedLine Citation:
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PMID: 23199324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma leptin in HT patients and the CD4(+) T cell-derived leptin from HT patients was stronger than that from healthy controls. In HT patients, there are no statistically significant correlations between plasma leptin concentrations and the percentage of Th17 cells or the level of retinoic acid-related orphan receptor γt (RORγt), but strong positive correlations were observed between CD4(+) T cell-derived leptin and the percentage of Th17 cells or the level of RORγt mRNA, and additionally significantly up-regulated leptin, interleukin (IL)17 and RORγt mRNA levels in the thyroid tissue. Furthermore, neutralization of leptin decreases the frequency of Th17 cells in vitro. Current study has revealed an increased leptin involvment in Hashimoto's thyroiditis associated with an increased number of Th17 cells. |
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Authors:
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S Wang; S E Baidoo; Y Liu; C Zhu; J Tian; J Ma; J Tong; J Chen; X Tang; H Xu; L Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 171 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-03 Completed Date: 2013-02-19 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 63-8 Citation Subset: IM |
Copyright Information:
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© 2012 British Society for Immunology. |
Affiliation:
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Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University School of Medical Science and Laboratory Medicine, Zhenjiang, China. sjwjs@ujs.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood, immunology CD4-Positive T-Lymphocytes / immunology, metabolism Female Hashimoto Disease / blood, immunology, metabolism* Humans Interleukin-17 / biosynthesis, immunology Leptin / blood* Leukocytes, Mononuclear / immunology Middle Aged Nuclear Receptor Subfamily 1, Group F, Member 3 / biosynthesis, immunology Th17 Cells / immunology* Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Interleukin-17; 0/Leptin; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine |
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