| T-cell-deficient mice display normal recovery from experimental rotavirus infection. | |
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MedLine Citation:
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PMID: 3484788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rotaviruses are common causes of diarrhea in animals and humans. Little is known, however, about the components of the host response to these viruses. Rotavirus infection was studied in athymic mice experimentally infected with murine rotavirus. Neonatal T-cell-deficient mice experienced a self-limited gastrointestinal infection which was identical to that observed in age-matched immunocompetent mice. Adult T-cell-deficient seronegative mice and age-matched normal mice showed a similar extent of resistance to symptomatic rotavirus infection. In both cases, the infection was resolved without the generation of antirotavirus antibody. These studies indicate that host defense against murine rotavirus requires neither functional T-lymphocytes nor specific antiviral antibody. |
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Authors:
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J Eiden; H M Lederman; S Vonderfecht; R Yolken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of virology Volume: 57 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-02-28 Completed Date: 1986-02-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 706-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / immunology, microbiology Antigens, Viral / analysis Feces / microbiology Mice Mice, Nude / immunology Rotavirus Infections / immunology* T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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N01 AI 22680/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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