Document Detail

T-cell cytokines in injury-induced neural damage and repair.
MedLine Citation:
PMID:  16247179     Owner:  NLM     Status:  MEDLINE    
T-cell cytokines are involved in beneficial immune responses, pathological autoimmunity, and tissue inflammation. In this review, we focus on the role of interferon-gamma, interleukin (IL)-2, IL-4, IL-6, and IL-10 in autoimmune diseases such as multiple sclerosis, and primarily "nonimmune" injury of the central nervous system (CNS), in particular focal ischemia and trauma. Resident CNS cells such as microglia and astroglia are additional, and on some occasions major, cellular sources of T-cell cytokines in CNS disease. Collectively, they mediate harmful as well as beneficial functions that depend on the dynamics, cellular source, and compartmental site of their release, the pathophysiological context, and the presence of coexpressed factors. Furthermore, direct neurotoxic and neuroprotective effects of cytokines are evident that are independent from their immunoregulating properties. Whereas these complex interactions are only beginning to be understood, T-cell cytokines nevertheless hold promise as therapeutic targets in a variety of neurological disease conditions.
Michael Schroeter; Sebastian Jander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neuromolecular medicine     Volume:  7     ISSN:  1535-1084     ISO Abbreviation:  Neuromolecular Med.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-25     Completed Date:  2006-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101135365     Medline TA:  Neuromolecular Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-95     Citation Subset:  IM    
Department of Neurology, Heinrich-Heine University, Düsseldorf, Germany.
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MeSH Terms
Astrocytes / metabolism
Autoimmune Diseases / immunology*
Brain Ischemia / immunology*
Cytokines / metabolism*
Microglia / metabolism
Nerve Regeneration / immunology*
T-Lymphocytes / metabolism*
Th1 Cells / metabolism
Th2 Cells / metabolism
Trauma, Nervous System / immunology*
Reg. No./Substance:

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