Document Detail

T-cell biology in immunotherapy.
MedLine Citation:
PMID:  24565594     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This review discusses the current state of immunotherapy and how the CD4 T-cell response is pivotal in altering the allergic response.
DATA SOURCES: PubMed literature review.
STUDY SELECTIONS: Articles pertaining to subcutaneous, sublingual, and oral immunotherapies, with specific emphasis on those describing the T-cell response.
RESULTS: Although many drugs are available that help ameliorate allergic symptoms, the only intervention that has proved to provide long-term benefit and modulation of disease is immunotherapy. Many routes of immunotherapy are being pursued, including subcutaneous, sublingual, and oral immunotherapies; however, subcutaneous immunotherapy has the historical record of leading to immune changes that alter the immune response at subsequent allergen exposure. These changes are mediated by the induction of peripherally derived T-regulatory cells and appear to occur only after high-dose therapy for 3 to 5 years. Newer methods of sublingual and oral immunotherapies are currently being investigated, but their efficacy is not yet on par with subcutaneous immunotherapy.
CONCLUSION: The primary cells ultimately responsible for successful immunomodulation are CD4 T cells, specifically peripherally derived T-regulatory cells.
John W Steinke; Monica G Lawrence
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2014-01-14
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  112     ISSN:  1534-4436     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-02-25     Completed Date:  2014-04-22     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Antigens, CD4 / metabolism
Desensitization, Immunologic / methods
Hypersensitivity / immunology,  therapy*
Immunotherapy / methods*
Injections, Subcutaneous
Interleukin-10 / immunology
Interleukin-2 Receptor alpha Subunit / metabolism
T-Lymphocytes, Regulatory / immunology*
Transforming Growth Factor beta / immunology
Grant Support
Reg. No./Substance:
0/Antigens, CD4; 0/Interleukin-2 Receptor alpha Subunit; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10

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