| T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes. | |
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MedLine Citation:
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PMID: 21039471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The non-obese diabetic (NOD) mouse model of autoimmune (type 1) diabetes has contributed greatly to our understanding of disease pathogenesis and has facilitated the development and testing of therapeutic strategies to combat the disease. Although the model is a valuable immunological tool in its own right, it reaches its fullest potential in areas where its findings translate to the human disease. Perhaps the foremost example of this is the field of T-cell antigen discovery, from which diverse benefits can be derived, including the development of antigen-specific disease interventions. The majority of NOD T-cell antigens are also targets of T-cell autoimmunity in patients with type 1 diabetes, and several of these are currently being evaluated in clinical trials. Here we review the journeys of these antigens from bench to bedside. We also discuss several recently identified NOD T-cell autoantigens whose translational potential warrants further investigation. |
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Authors:
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Jeffrey Babad; Ari Geliebter; Teresa P DiLorenzo |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-10-13 |
Journal Detail:
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Title: Immunology Volume: 131 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-10 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 459-65 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Immunology © 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantigens / immunology* Diabetes Mellitus, Experimental / immunology* Diabetes Mellitus, Type 1 / immunology* Humans Mice Mice, Inbred NOD T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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NS07098/NS/NINDS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Autoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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