Document Detail

T-cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome.
MedLine Citation:
PMID:  6608369     Owner:  NLM     Status:  MEDLINE    
A case of childhood T-cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p-). Cytogenetic studies at relapse showed, in addition to 9p-, a partial deletion of the long arm of one chromosome 6 (6q-) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q-). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T-cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.
B A Miller; M M Reid; M Nell; J M Lipton; S E Sallan; D G Nathan; R Tantravahi
Related Documents :
395589 - Chromosome changes and benzene exposure. a review.
3232749 - Comparative clinicopathological study on pityriasis lichenoides chronica and small plaq...
12691999 - Recsim and indstats: probabilities of identity in general genealogies.
15672989 - Pneumomediastinum in student aviators: 10 cases with return to flying duty.
8497319 - In utero rearrangements in the trithorax-related oncogene in infant leukaemias.
269009 - Quantification by dna-based cytophotometry of the 9q+/22q-chromosomal translocation ass...
6945149 - Dicentric isochromosome for the long arm of chromosome #17, dic i(17q), in a patient wi...
14688169 - Analysis of chromosomal abnormalities in testicular and epididymal spermatozoa from azo...
9247329 - Genetic separation of the neural and cuticular patterning functions of gooseberry.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of haematology     Volume:  56     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Marrow / ultrastructure
Child, Preschool
Chromosome Aberrations / genetics*
Chromosome Deletion
Chromosome Disorders
Chromosomes, Human, 21-22 and Y / ultrastructure*
Chromosomes, Human, 6-12 and X / ultrastructure
Leukemia, Lymphoid / genetics*
Time Factors
Translocation, Genetic
Grant Support
P01 CA18662-07/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chronic myelodysplastic syndrome: short survival with or without evolution to acute leukaemia.
Next Document:  Blue fleck corneal iridescence: an occasional feature of Cogan's microcystic corneal dystrophy.