Document Detail


T-cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome.
MedLine Citation:
PMID:  6608369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of childhood T-cell acute lymphoblastic leukaemia (ALL) is presented in which the only chromosome abnormality at diagnosis was a deletion of part of the short arm of one chromosome 9 (9p-). Cytogenetic studies at relapse showed, in addition to 9p-, a partial deletion of the long arm of one chromosome 6 (6q-) and the Philadelphia chromosome (Ph1) produced as a result of the classical translocation t(9q+;22q-). All metaphases from haemopoietic colonies grown from a cryopreserved specimen of this patient's marrow at relapse were normal, in contrast to haemopoietic colonies cultured from patients with chronic myelogenous leukaemia (CML) which contained the Ph1. A hypothesis which incorporates T-cell ALL with late development of the Ph1 into the overall family of Ph1 positive diseases is suggested.
Authors:
B A Miller; M M Reid; M Nell; J M Lipton; S E Sallan; D G Nathan; R Tantravahi
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of haematology     Volume:  56     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow / ultrastructure
Child, Preschool
Chromosome Aberrations / genetics*
Chromosome Deletion
Chromosome Disorders
Chromosomes, Human, 21-22 and Y / ultrastructure*
Chromosomes, Human, 6-12 and X / ultrastructure
Humans
Karyotyping
Leukemia, Lymphoid / genetics*
Male
T-Lymphocytes
Time Factors
Translocation, Genetic
Grant Support
ID/Acronym/Agency:
P01 CA18662-07/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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