Document Detail

T cell activation surface markers and autologous mixed lymphocyte reaction do not differ in true and pseudo food allergy.
MedLine Citation:
PMID:  2953685     Owner:  NLM     Status:  MEDLINE    
Eighteen patients affected by itching, urticaria, eczema, angioedema, and asthma related to food-stuff intake were studied and classified in two groups (true food allergy and pseudoallergy) on the basis of clinical data, skin prick tests, total and specific IgE levels (PRIST and RAST) and double-blind challenge test. Autologous mixed lymphocyte reaction (AMLR) and T cell activation markers were thought to be tests possibly useful to discriminate between 'true' food allergy and 'pseudoallergy'. The present study failed to show either a significant increase in T cell activation markers (MLR4, Ia) or a significant decrease in AMLR proliferation in such subjects as compared to normal controls. In addition, we found no differences between 'true' allergic and 'pseudoallergic' patients on the basis of the parameters evaluated. Although the AMLR defect was reported both in asthma and in dermatitis, and therefore was thought to be related to atopy, the present data do not confirm this hypothesis in 'true' food allergy.
W Dirienzo; G Ciprandi; M Caria; A Scordamaglia; M Bagnasco; G W Canonica; H H Fudenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  83     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-15     Completed Date:  1987-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
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MeSH Terms
Antigens, Surface / analysis
Asthma / immunology
Dermatitis / immunology
Food Hypersensitivity / immunology*
Histocompatibility Antigens Class II / analysis
Hypersensitivity / immunology
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Antigens, Surface; 0/Histocompatibility Antigens Class II

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