| T-cell Subsets and Antifungal Host Defenses. | |
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MedLine Citation:
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PMID: 20976286 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It has been long appreciated that protective immunity against fungal pathogens is dependent on activation of cellular adaptive immune responses represented by T lymphocytes. The T-helper (Th)1/Th2 paradigm has proven to be essential for the understanding of protective adaptive host responses. Studies that have examined the significance of regulatory T cells in fungal infection, and the recent discovery of a new T-helper subset called Th17 have provided crucial information for understanding the complementary roles played by the various T-helper lymphocytes in systemic versus mucosal antifungal host defense. This review provides an overview of the role of the various T-cell subsets during fungal infections and the reciprocal regulation between the T-cell subsets contributing to the tailored host response against fungal pathogens. |
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Authors:
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Frank L van de Veerdonk; Mihai G Netea |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-9-30 |
Journal Detail:
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Title: Current fungal infection reports Volume: 4 ISSN: 1936-377X ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101306636 Medline TA: Curr Fungal Infect Rep Country: - |
Other Details:
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Languages: ENG Pagination: 238-243 Citation Subset: - |
Affiliation:
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Department of Medicine (463), Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, Nijmegen, 6525 GA The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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