| T-cell Acute Lymphoblastic Leukemia Associated with Complex Karyotype and SET-NUP214 Rearrangement: A Case Study and Review of the Literature. | |
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MedLine Citation:
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PMID: 22075511 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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SET-NUP214 rearrangements have been rarely reported in T-cell acute lymphoblastic leukemia (T-ALL), acute undifferentiated leukemia, and acute myeloid leukemia, and most documented cases have been associated with normal karyotypes in conventional cytogenetic analyses. Here, we describe a novel case of T-ALL associated with a mediastinal mass and a SET-NUP214 rearrangement, which was masked by a complex karyotype at the time of initial diagnosis. Using multiplex reverse transcriptase-polymerase chain reaction analysis, we detected a cryptic SET-NUP214 rearrangement in our patient. As only 11 cases (including the present study) of T-ALL with SET-NUP214 rearrangement have been reported, the clinical features and treatment outcomes have not been fully determined. Further studies are necessary to evaluate the incidence of SET-NUP214 rearrangement in T-ALL patients and the treatment responses as well as prognosis of these patients. |
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Authors:
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Sang-Guk Lee; Tae Sung Park; Sun Young Cho; Gayoung Lim; Gwang Jin Park; Seung Hwan Oh; Eun Hae Cho; So Young Chong; Ji Young Huh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 41 ISSN: 1550-8080 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: United States |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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