Document Detail


T-box 3 is expressed in the adult mouse hypothalamus and medulla.
MedLine Citation:
PMID:  19765559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using microarray analysis, in situ hybridization and immunocytochemistry, we found that the transcription factor TBX3 is produced in three discrete neuronal populations of the adult mouse brain, the arcuate nucleus (including in NPY but not dopaminergic neurons), the histaminergic tuberomammillary nucleus and in cholinergic neurons of the solitary tract nucleus. The immunoreactive protein had a nuclear location in these neurons, consistent with its function as a transcription factor. Although the function of tbx3 in these neurons is unknown, a review of the literature strongly suggests that these neuronal populations may be abnormal in Ulnar-Mammary syndrome patients with tbx3 mutations, explaining previously overlooked phenotypes in this syndrome, such as obesity, sexual dysfunction and possibly sleep abnormalities.
Authors:
Krister S Eriksson; Emmanuel Mignot
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-09-16
Journal Detail:
Title:  Brain research     Volume:  1302     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-02-23     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Animals
Arcuate Nucleus / cytology,  metabolism*
Brain Mapping
Cell Nucleus / metabolism,  ultrastructure
Gene Expression Regulation / physiology
Hypothalamic Area, Lateral / cytology,  metabolism*
Immunohistochemistry
Male
Mice
Mice, Inbred C57BL
Neurons / cytology,  metabolism*
Neuropeptide Y / metabolism
Obesity / genetics,  metabolism,  physiopathology
Solitary Nucleus / cytology,  metabolism*
Syndrome
T-Box Domain Proteins / analysis,  metabolism*
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
MH073435/MH/NIMH NIH HHS; P50 NS023724/NS/NINDS NIH HHS; P50 NS023724-22/NS/NINDS NIH HHS; R01 MH073435/MH/NIMH NIH HHS; R01 MH073435-05/MH/NIMH NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/T-Box Domain Proteins; 0/Tbx3 protein, mouse; 0/Transcription Factors; N9YNS0M02X/Acetylcholine
Comments/Corrections

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