Document Detail


The T-allele of the C825T polymorphism is associated with higher arterial stiffness in young healthy males.
MedLine Citation:
PMID:  15037876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial stiffening is the major cause of increasing systolic blood pressure in arterial hypertension. Increased arterial stiffness is one major mechanism responsible for morbidity and mortality in hypertension. A C825T polymorphism was identified in the gene encoding the G-protein beta3 subunit (GNB3), and an association of the T-allele with hypertension was demonstrated in several studies. In order to identify a pathogenetic link between hypertension and arterial stiffness, we compared two indices of arterial stiffness, pulse wave velocity (PWV) and augmentation index, in young, healthy men with and without the 825T-allele under resting conditions. PWV was determined from pressure tracing over carotid and femoral arteries in 99 subjects (CC: n=43; CT&TT: n=56). Augmentation index was derived in 72 subjects (CC: n=30; CT&TT: n=42) by pulse wave analysis using radial applanation tonometry. Carriers of the 825T-allele exhibited a significantly higher PWV compared to subjects with the CC genotype (6.0+/-0.1 m/s (TC&TT) vs 5.7+/-0.1 m/s (CC); P=0.0251). There was also a significant difference (P = 0.0448) in augmentation index between carriers of the T-allele (CT&TT: 3.4+/-2.9%) and controls with the CC -genotype (-5.0+/-4.1 %). There was no difference in any other anthropometric (age, height, weight, body mass index) or haemodynamic (heart rate, peripheral and central blood pressure). In summary, the C825T polymorphism is associated with higher arterial stiffness in young, healthy males. Arterial stiffening may pathogenetically contribute to the development of hypertension in carriers of the T-allele.
Authors:
J Nürnberger; A Opazo Saez; A Mitchell; S Bührmann; R R Wenzel; W Siffert; T Philipp; R F Schäfers
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Hypertension, Essen, Germany. jens.nuernberger@uni-essen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Alleles*
Aorta / physiopathology*
Arterial Occlusive Diseases / genetics*,  physiopathology*
Blood Flow Velocity / genetics
Blood Pressure / genetics
Diastole / physiology
Genetic Predisposition to Disease / genetics
Genotype
Heart Rate / genetics
Humans
Hypertension / genetics,  physiopathology
Male
Polymorphism, Genetic / genetics*
Statistics as Topic
Systole / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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