| T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. | |
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MedLine Citation:
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PMID: 20951945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The molecular events underlying the progression of T-lymphoblastic lymphoma (T-LBL) to acute T-lymphoblastic leukemia (T-ALL) remain elusive. In our zebrafish model, concomitant overexpression of bcl-2 with Myc accelerated T-LBL onset while inhibiting progression to T-ALL. The T-LBL cells failed to invade the vasculature and showed evidence of increased homotypic cell-cell adhesion and autophagy. Further analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-LBL compared with T-ALL. Inhibition of S1P1 signaling in T-LBL cells led to decreased homotypic adhesion in vitro and increased tumor cell intravasation in vivo. Thus, blockade of intravasation and hematologic dissemination in T-LBL is due to elevated S1P1 signaling, increased expression of ICAM1, and augmented homotypic cell-cell adhesion. |
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Authors:
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Hui Feng; David L Stachura; Richard M White; Alejandro Gutierrez; Lu Zhang; Takaomi Sanda; Cicely A Jette; Joseph R Testa; Donna S Neuberg; David M Langenau; Jeffery L Kutok; Leonard I Zon; David Traver; Mark D Fleming; John P Kanki; A Thomas Look |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer cell Volume: 18 ISSN: 1878-3686 ISO Abbreviation: Cancer Cell Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2010-11-03 Revised Date: 2013-02-15 |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
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Languages: eng Pagination: 353-66 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Autophagy Blood Vessels / enzymology, pathology* Cell Aggregation Cell Line, Tumor Cell Movement Disease Progression Enzyme Activation Gene Expression Regulation, Leukemic Humans Immunohistochemistry Intercellular Adhesion Molecule-1 / genetics, metabolism* Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / enzymology, genetics, metabolism*, pathology* Proto-Oncogene Proteins c-akt / metabolism Proto-Oncogene Proteins c-bcl-2 / genetics, metabolism* Proto-Oncogene Proteins c-myc / metabolism Receptors, Lysosphingolipid / antagonists & inhibitors, genetics, metabolism* Zebrafish |
| Grant Support | |
ID/Acronym/Agency:
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1K01DK074555/DK/NIDDK NIH HHS; 1K08CA133103/CA/NCI NIH HHS; 3K01AR055619-03S1/AR/NIAMS NIH HHS; CA068484/CA/NCI NIH HHS; CA077429/CA/NCI NIH HHS; K01 AR055619/AR/NIAMS NIH HHS; K01AR05562190-01A1/AR/NIAMS NIH HHS; K08 CA133103/CA/NCI NIH HHS; K08 CA133103-01/CA/NCI NIH HHS; K08 CA133103-02/CA/NCI NIH HHS; K08 CA133103-03/CA/NCI NIH HHS; K08 CA133103-04/CA/NCI NIH HHS; K99 CA134743-01A1/CA/NCI NIH HHS; K99CA134743/CA/NCI NIH HHS; L40 CA124083-01/CA/NCI NIH HHS; L40 CA124083-02/CA/NCI NIH HHS; R00 CA134743/CA/NCI NIH HHS; R01 CA077429-13/CA/NCI NIH HHS; T32-HL086344/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 0/Proto-Oncogene Proteins c-myc; 0/Receptors, Lysosphingolipid; 126547-89-5/Intercellular Adhesion Molecule-1; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
| Comments/Corrections | |
Comment In:
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Cancer Cell. 2010 Oct 19;18(4):297-9
[PMID:
20951938
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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