| T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. | |
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MedLine Citation:
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PMID: 22492686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memory-like CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus. |
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Authors:
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Archna Sharma; Qinghua Chen; Trang Nguyen; Qing Yu; Jyoti Misra Sen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 188 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-11 Completed Date: 2012-06-21 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 3859-68 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD8 / genetics, immunology Cell Movement / immunology Gene Expression Regulation / immunology Humans Immunity, Innate Immunologic Memory* Interferon-gamma / biosynthesis, immunology Interleukin-4 / biosynthesis, immunology Kruppel-Like Transcription Factors / genetics, immunology Mice Mice, Transgenic Receptors, Interleukin-4 / genetics, immunology Signal Transduction / immunology T Cell Transcription Factor 1 / deficiency, genetics, immunology* T-Box Domain Proteins / genetics, immunology Thymocytes / cytology, immunology*, physiology beta Catenin / genetics, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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Z99 AG999999/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD8; 0/Eomes protein, mouse; 0/Kruppel-Like Transcription Factors; 0/Receptors, Interleukin-4; 0/T Cell Transcription Factor 1; 0/T-Box Domain Proteins; 0/Tcf7 protein, mouse; 0/beta Catenin; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
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