Document Detail

T and B lymphocytes during normal human pregnancy: a longitudinal study.
MedLine Citation:
PMID:  317536     Owner:  NLM     Status:  MEDLINE    
Immunological relationships in pregnancy were investigated in a longitudinal study of twenty-two pregnant women, whose blood samples were taken before pregnancy, during pregnancy, at delivery, and 3--5 months after delivery. Blood samples were also taken from the fathers and the infants, both at birth and after 3--5 months. All the samples were frozen by means of a cryobiological freezing system, and when a whole longtiudinal series had been collected, the material was thawed and tested in a single seance. T and B lymphocytes were studied with rosette tests (E and HEAC rosettes). T and B lymphocytes were found not to change during the course of pregnancy. It is thus concluded that the mother's tolerance of a fetus with a dissimilar tissue type is not exercised via changes in the total count of T and B lymphocytes, although there may well be changes in their subpopulations, with the hypothesis that T-suppressor function increases and B-lymphocyte function decreases.
S A Birkeland; K Kristoffersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  10     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1979  
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / immunology*
Blood Specimen Collection
Gestational Age
Infant, Newborn
Leukocyte Count
Longitudinal Studies
Rosette Formation
T-Lymphocytes / immunology*

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