Document Detail


T and B lymphocyte subsets in patients with unexplained recurrent spontaneous abortion: IVIG versus placebo treatment.
MedLine Citation:
PMID:  12516653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: To investigate circulating lymphocyte subsets in women with recurrent spontaneous abortion (RSA) in relation to pregnancy outcome and to treatment with intravenous immunoglobulin (IVIG). METHOD OF STUDY: Forty-one women with a history of unexplained RSA were examined during first trimester of pregnancy before IVIG or placebo treatment and after pregnancy. The results were compared with five healthy, non-pregnant women and five women in the first trimester of normal pregnancy. Circulating lymphocyte subsets with focus on T-cell subpopulations were determined by flow cytometry. RESULTS: The proportions of human leukocyte antigen (HLA)-DR positive T cells (CD3+ HLA-DR+), T-killer/effector cells (CD8+ S6F1+) and B cells (CD19+) were increased, whereas the proportion of T-suppressor/inducer cells (CD4+ CD45RA+) was decreased during first trimester pregnancy of RSA women compared with pregnant normal controls. T and B lymphocyte subsets did not correlate with pregnancy outcome on either IVIG or placebo group. CONCLUSIONS: In RSA patients, the immune system seems to be activated in contrast to the suppression noted in normal pregnancy.
Authors:
Barbara Jablonowska; Miodrag Palfi; Leif Matthiesen; Anders Selbing; Svante Kjellberg; Jan Ernerudh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  48     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-08     Completed Date:  2003-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  312-8     Citation Subset:  IM    
Affiliation:
Division of Obstetrics and Gynecology, Department of Health and Environment, University Hospital, Linköping, Sweden. barbara.jablonowska@lio.se
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / drug therapy*,  immunology*
Adult
B-Lymphocyte Subsets / drug effects,  immunology*
Female
Humans
Immunoglobulins, Intravenous / administration & dosage,  immunology*
Pregnancy / drug effects,  immunology
T-Lymphocyte Subsets / drug effects,  immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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