Document Detail

T- and B-cell distribution in pregnancy.
MedLine Citation:
PMID:  306448     Owner:  NLM     Status:  MEDLINE    
We established the percentage of thymus-derived lymphocytes associated with cellular immune responses and bone marrow-derived, antibody-producing cells in maternal blood throughout normal gestation. The data are in conflict with a recent proposal that reversal ot the T:B cell ratio associated with the serum human chorionic gonadotrophin peak of early pregnancy assists in fetoplacental allograft acceptance. Moreover, variability on lymphocyte dynamics in four women followed up serially throughout pregnancy, as well as T- and B-cell determinations in 15 patients whose pregnancy complications are potentially related to maternal-fetal immunologic aberrations, suggests that more sensitive immunologic methods of monitoring the host immune response are necessary to be clinically useful in obstetrics.
J R Scott; T L Feldbush
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  239     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2769-71     Citation Subset:  AIM; IM    
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MeSH Terms
B-Lymphocytes* / immunology
Fetus / immunology
Leukocyte Count*
Placenta / immunology
Pregnancy Complications* / immunology
Pregnancy Trimester, First
T-Lymphocytes* / immunology

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