| Systolic versus Diastolic Acquisition in Myocardial Perfusion MR Imaging. | |
| | |
MedLine Citation:
|
PMID: 22357884 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Purpose: To compare myocardial blood flow (MBF) at systole and diastole and determine the diagnostic accuracy of both phases in patients suspected of having coronary artery disease (CAD). Materials and Methods: The study was approved by the regional ethics committee, and all patients gave written informed consent. After coronary angiography, 40 patients (27 men; mean age, 64 years ± 8) underwent stress-rest perfusion magnetic resonance (MR) imaging at 1.5 T, with images aquired simultaneously at end systole and middiastole. Patients were classified as having CAD (stenosis .70%) or no significant CAD. In patients with CAD, myocardial segments were classified as stenosis-dependent (downstream of significant stenosis) or remote. MBF and myocardial perfusion reserve (MPR) were calculated for each segment, and mean values in each phase were compared with paired t tests. The diagnostic accuracy of each phase was determined with receiver operating characteristic (ROC) analysis. Results: Twenty-one of the 40 patients (53%) had CAD. Resting MBF was similar in both phases for patients with and patients without CAD (P > .05). Stress MBF was greater in diastole than systole in normal, remote, and stenosis-dependent segments (3.75 mL/g/min ± 1.50 vs 3.15 mL/g/min ± 1.10, respectively, for normal segments; 2.75 mL/g/min ± 1.20 vs 2.38 mL/g/min ± 0.99, respectively, for remote segments; 2.49 mL/g/min ± 1.07 vs 2.23 mL/g/min ± 0.90, respectively, for stenosis-dependent segments; P <.01). MPR was greater in diastole than systole in all segment groups (P < .05). The diagnostic accuracies at diastole and systole were similar (area under the ROC curve = 0.79 and 0.82, respectively; P = .30). Conclusion: Myocardial perfusion MR estimates of stress MBF and MPR were greater in diastole than systole in patients with and patients without CAD. However, both phases had similar diagnostic accuracy. These observations may be relevant to other dynamic perfusion methods, including computed tomography and echocardiography. © RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11111549/-/DC1. |
| | |
Authors:
|
Manish Motwani; Timothy A Fairbairn; Abdulghani Larghat; Adam N Mather; John D Biglands; Aleksandra Radjenovic; John P Greenwood; Sven Plein |
Related Documents
:
|
6142464 - Beta-blockers in the secondary prevention of myocardial infarction: a review of clinica... 6118124 - Beta blockade and the effects of stress on the normal and ischaemic heart. 22812924 - Association between the amount of right-to-left shunt and infarct patterns in patients ... 17023204 - International variations in the treatment and co-morbidity of left ventricular systolic... 6881354 - Hyaluronidase reversal of increased coronary vascular resistance in ischemic rat hearts. 10517404 - Fatal bacterial endocarditis following aortic valve replacement in a patient being trea... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Radiology Volume: 262 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 816-23 Citation Subset: AIM; IM |
Affiliation:
|
Multidisciplinary Cardiovascular Research Centre & Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, England; Division of Medical Physics, University of Leeds, Leeds, England. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of mammography detection on the course of breast cancer in women aged 40-49 years.
Next Document: Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablati...