| Systolic hypertension in the elderly: addressing an unmet need. | |
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MedLine Citation:
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PMID: 18328297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systolic hypertension is a major public health issue in the elderly and is often under-recognized and under-treated. The concept that systolic blood pressure increases with age should be considered a pathophysiologic concept. Aging of the cardiovascular system is accompanied by endothelial dysfunction, activation of the renin-angiotensin system and, consequently, vascular remodeling. This process leads to an increase in large artery stiffness and an increase in arterial wave reflections to the heart. These processes in daily clinical practice translate to an increase in systolic blood pressure, which is associated with increased cardiovascular morbidity and mortality. Evidence-based medicine recommendations to treat systolic hypertension in the elderly are based on landmark and recent clinical trials, which clearly demonstrated that treatment of isolated systolic hypertension is associated with significant decreases in cardiovascular morbidity and mortality. However, treatment of systolic hypertension in older adults remains disappointing because therapeutic goals often are not reached. Therefore, emphasis should be placed on the treatment of systolic hypertension in the elderly, and there is need for more effective, individualized antihypertensive therapy. |
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Authors:
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Daniel A Duprez |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of medicine Volume: 121 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-10 Completed Date: 2008-03-27 Revised Date: 2008-09-18 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 179-184.e3 Citation Subset: AIM; IM |
Affiliation:
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Cardiovascular Division, Medical School, University of Minnesota, MN 55455, USA. dupre007@umn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use* Humans Hypertension / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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Am J Med. 2008 Sep;121(9):e21, author reply e23
[PMID:
18724948
]
Am J Med. 2008 Sep;121(9):e15 [PMID: 18724945 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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