| Systolic heterogeneity of transmural myocardial function in normal subjects: physiological functional heterogeneity. | |
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MedLine Citation:
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PMID: 12365559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because of the lack of a clinical method for assessing the transmural myocardial function, few studies on the heterogeneity during the myocardial contraction/relaxation sequence inside the human ventricular wall have been reported, despite the fact that the importance of the pathophysiology in the transmural heterogeneity has been stressed in previous experimental studies. We studied the transmyocardial functional heterogeneity of the basal anteroseptal segment in normal subjects (n = 8, 40.0 +/- 12.8 year, male), adopting the novel high resolution Doppler measurement "Phased Tracking Method". Each transmural layer of 0.75 mm thickness showed functional heterogeneity (physiological transmural functional heterogeneity), namely larger thickening occurred in the left ventricular endocardial side (right side 1/3: 26.1 +/- 5.2% of the total wall thickness, middle 1/3: 31.9 +/- 2.7%, left side 1/3: 42.1 +/- 6.4%) and the peak thickening shifted smoothly in time from the middle layers to the left subendocardial side during the contraction period. We concluded that transmural functional heterogeneity does exist in normal subjects as well as in the experimental animals of previous reports. Smooth and coordinate myocardial layer contraction across the ventricular wall (physiological transmural functional heterogeneity) is fundamental to maintain the normal ventricular function. |
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Authors:
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Yoshiro Koiwa; Hideichi Kamada; Mikio Inose; Kunio Shirato; Yoshiko Saito; Hideyuki Hasegawa; Hiroshi Kanai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 197 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-10-07 Completed Date: 2003-04-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: Japan |
Other Details:
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Languages: eng Pagination: 183-7 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. koiwa@int1.med.tohoku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Echocardiography Heart / physiology Humans Male Middle Aged Myocardial Contraction* Systole / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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