Document Detail


Systolic blood pressure within an intermediate range may reduce memory loss in an elderly hypertensive cohort.
MedLine Citation:
PMID:  10447147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine if maintenance of systolic blood pressure (BP) within a high range or low range among treated hypertensive patients increases the risk of memory decline. Biennial neuropsychological evaluations were performed on 158 hypertensive subjects. Decline/year was measured on the Cued Selective Reminding test (total free recall and delayed recall) in three systolic BP groups (low-i.e., mean systolic BP during the follow-up period < 135 mm Hg; intermediate-i.e., 135 mm Hg < or = mean systolic BP < or = 150 mm Hg; high-i.e., mean systolic BP > 150 mm Hg). In total free recall, the three systolic BP groups had significantly different declines per year (P = .02), with patients in the high subgroup showing the greatest decline. In delayed recall, the three systolic BP groups also showed significantly different declines per year (P = .04), with patients in the low subgroup having the greatest decline. Chronically elevated systolic BP > 150 mm Hg is associated with accelerated memory decline compared to older treated hypertensive patients with systolic BP in an intermediate range. Chronically maintained systolic BP within a low normal range < 135 mm Hg in older treated hypertensive subjects may be associated with accelerated memory decline, specifically in a test of delayed memory recall, compared to patients with systolic BP in an intermediate range. Optimal regulation of systolic BP may be a potential modifiable risk factor to prevent or minimize memory loss in older hypertensive patients.
Authors:
N Sacktor; S Gray; C Kawas; J Herbst; P Costa; J Fleg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  12     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:  1999  
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / therapeutic use
Blood Pressure / physiology*
Cohort Studies
Female
Follow-Up Studies
Humans
Hypertension / complications*,  drug therapy
Male
Memory Disorders / diagnosis,  etiology*,  prevention & control*
Middle Aged
Neuropsychological Tests
Retrospective Studies
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
AG05146/AG/NIA NIH HHS; AG08325/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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