| Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. | |
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MedLine Citation:
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PMID: 22244788 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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With a world market of more than four million tons per year, l-amino acids are among the most important products in industrial biotechnology. The recent years have seen a tremendous progress in the development of tailor-made strains for such products, intensively driven from systems metabolic engineering, which upgrades strain engineering into a concept of optimization on a global scale. This concept seems especially valuable for efficient amino acid production, demanding for a global modification of pathway fluxes - a challenge with regard to the high complexity of the underlying metabolism, superimposed by various layers of metabolic and transcriptional control. |
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Authors:
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Judith Becker; Christoph Wittmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Current opinion in biotechnology Volume: - ISSN: 1879-0429 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100492 Medline TA: Curr Opin Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Biochemical Engineering, Technische Universität Braunschweig, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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