| Systems-level feedback in cell-cycle control. | |
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MedLine Citation:
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PMID: 20863292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism). |
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Authors:
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Béla Novák; P K Vinod; Paula Freire; Orsolya Kapuy |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 38 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1242-6 Citation Subset: IM |
Affiliation:
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Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. bela.novak@bioch.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CDC2 Protein Kinase / genetics, metabolism Cell Cycle / genetics, physiology* Cell Cycle Proteins / genetics, metabolism Cyclin B / genetics, metabolism Feedback, Physiological / physiology* Humans |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Cyclin B; EC 2.7.11.22/CDC2 Protein Kinase |
| Comments/Corrections | |
Erratum In:
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Biochem Soc Trans. 2010 Dec;38(6):1723 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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