| Systems biology in a commercial quality study of the Japanese angelica radix: toward an understanding of traditional medicinal plants. | |
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MedLine Citation:
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PMID: 21721155 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The commercial quality of Japanese Angelica radices - Angelica acutiloba Kitagawa (Yamato-toki) and A. acutiloba Kitagawa var. sugiyama Hikino (Hokkai-toki) - used in Kampo traditional herbal medicines, was studied by use of omics technologies. Complementary and alternative medical providers have observed in their clinical experience that differences in radix commercial quality reflect the differences in pharmacological responses; however, there has been little scientific examination of this phenomenon. The approach of omics, including metabolomics, transcriptomics, genomics, and informatics revealed a distinction between the radix-quality grades based on their metabolites, gene expression in human subjects, and plant genome sequences. Systems biology, constructing a network of omics data used to analyze this complex system, is expected to be a powerful tool for enhancing the study of radix quality and furthering a comprehensive understanding of all medicinal plants. |
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Authors:
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Akira Katoh; Shinzo Fukuda; Eiichiro Fukusaki; Takashi Hashimoto; Tomoyuki Hayasaki; Shigehiko Kanaya; Hajime Komura; Kyosuke Nomoto; Masayuki Shojo; Kanokwan Jumtee Takeno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of Chinese medicine Volume: 39 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 757-77 Citation Subset: IM |
Affiliation:
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Core Laboratory, Nara Prefectural Small and Medium-Sized Enterprises Support Corporation, 88 Shijo, Kashihara, Nara 634-0813, Japan. akira-katoh@bs.naist.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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