| Systems biology of the cell cycle of Saccharomyces cerevisiae: From network mining to system-level properties. | |
| | |
MedLine Citation:
|
PMID: 19465107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Following a brief description of the operational procedures of systems biology (SB), the cell cycle of budding yeast is discussed as a successful example of a top-down SB analysis. After the reconstruction of the steps that have led to the identification of a sizer plus timer network in the G1 to S transition, it is shown that basic functions of the cell cycle (the setting of the critical cell size and the accuracy of DNA replication) are system-level properties, detected only by integrating molecular analysis with modelling and simulation of their underlying networks. A detailed network structure of a second relevant regulatory step of the cell cycle, the exit from mitosis, derived from extensive data mining, is constructed and discussed. To reach a quantitative understanding of how nutrients control, through signalling, metabolism and transcription, cell growth and cycle is a very relevant aim of SB. Since we know that about 900 gene products are required for cell cycle execution and control in budding yeast, it is quite clear that a purely systematic approach would require too much time. Therefore lines for a modular SB approach, which prioritises molecular and computational investigations for faster cell cycle understanding, are proposed. The relevance of the insight coming from the cell cycle SB studies in developing a new framework for tackling very complex biological processes, such as cancer and aging, is discussed. |
| | |
Authors:
|
Lilia Alberghina; Paola Coccetti; Ivan Orlandi |
Related Documents
:
|
21191517 - Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. 11999577 - Cell cycle retardation in monocytoid cells induced by aminopeptidase n (cd13). 6667267 - Specific g1-s phase cell cycle block by beryllium as demonstrated by cytofluorometric a... 16903217 - Cell cycle regulation in mammalian germ cells. 4926207 - In vitro organization of dissociated rat cardiac cells into beating three-dimensional s... 18752547 - Cultural characteristics of salmonid alphaviruses - influence of cell line and temperat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-05-22 |
Journal Detail:
|
Title: Biotechnology advances Volume: 27 ISSN: 1873-1899 ISO Abbreviation: Biotechnol. Adv. Publication Date: 2009 Nov-Dec |
Date Detail:
|
Created Date: 2009-10-12 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8403708 Medline TA: Biotechnol Adv Country: England |
Other Details:
|
Languages: eng Pagination: 960-78 Citation Subset: IM |
Affiliation:
|
Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milano, Italy. lilia.alberghina@unimib.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle* Saccharomyces cerevisiae / cytology* Systems Biology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The hard choice for alternative biofuels to diesel in Brazil.
Next Document: Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of syn...