| Systems biology approaches to finding novel pain mediators. | |
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MedLine Citation:
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PMID: 23059966 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic pain represents a major health burden; this maladaptive pain state occurs as a consequence of hypersensitivity within the peripheral and central components of the somatosensory system. High throughput technologies (genomics, transciptomics, lipidomics, and proteomics) are now being applied to tissue derived from pain patients as well as experimental pain models to discover novel pain mediators. The use of clustering, meta-analysis and other techniques can help refine potential candidates. Of particular importance are systems biology methods, such as co-expression network generating algorithms, which infer potential associations/interactions between molecules and build networks based on these interactions. Protein-protein interaction networks allow the lists of potential targets generated by these different platforms to be analyzed in their biological context. Outputs from these different methods must also be related to the clinical pain phenotype. The improved and standardized phenotyping of pain symptoms and sensory signs enables much better subject stratification. Our hope is that, in the future, the use of computational approaches to integrate datasets including sensory phenotype as well as the outputs of high throughput technologies will help define novel pain mediators and provide insights into the pathogenesis of chronic pain. WIREs Syst Biol Med 2012. doi: 10.1002/wsbm.1192 For further resources related to this article, please visit the WIREs website. |
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Authors:
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Ana Antunes-Martins; James R Perkins; Jonathan Lees; Tobias Hildebrandt; Christine Orengo; David L H Bennett |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
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Title: Wiley interdisciplinary reviews. Systems biology and medicine Volume: - ISSN: 1939-005X ISO Abbreviation: Wiley Interdiscip Rev Syst Biol Med Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101516550 Medline TA: Wiley Interdiscip Rev Syst Biol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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The Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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