| Systems biology of Caulobacter. | |
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MedLine Citation:
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PMID: 18076330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dynamic range of a bacterial species' natural environment is reflected in the complexity of its systems that control cell cycle progression and its range of adaptive responses. We discuss the genetic network and integrated three-dimensional sensor/response systems that regulate the cell cycle and asymmetric cell division in the bacterium Caulobacter crescentus. The cell cycle control circuitry is tied closely to chromosome replication and morphogenesis by multiple feedback pathways from the modular functions that implement the cell cycle. The sophistication of the genetic regulatory circuits and the elegant integration of temporally controlled transcription and protein synthesis with spatially dynamic phosphosignaling and proteolysis pathways, and epigenetic regulatory mechanisms, form a remarkably robust living system. |
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Authors:
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Michael T Laub; Lucy Shapiro; Harley H McAdams |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of genetics Volume: 41 ISSN: 0066-4197 ISO Abbreviation: Annu. Rev. Genet. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0117605 Medline TA: Annu Rev Genet Country: United States |
Other Details:
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Languages: eng Pagination: 429-41 Citation Subset: IM |
Affiliation:
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Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. laub@mit.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Caulobacter
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cytology,
physiology* Cell Cycle Signal Transduction Systems Biology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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