Document Detail


Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers.
MedLine Citation:
PMID:  11486241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress plays an important role in the development of atherosclerosis and contributes to tissue damage that occurs as a consequence, particularly in myocardial infarction and acute stroke. Antioxidant properties of uric acid have long been recognized and, as a result of its comparatively high serum concentrations, it is the most abundant scavenger of free radicals in humans. Elevation of serum uric acid concentration occurs as a physiologic response to increased oxidative stress-for example, during acute exercise-thus providing a counter-regulatory increase in antioxidant defenses. In view of its antioxidant properties, uric acid may have potentially important and beneficial effects within the cardiovascular system. We wished to investigate whether administration of uric acid was feasible and if it could have an impact on antioxidant function in vivo. We have, therefore, performed a randomized, placebo-controlled double-blind study of the effects of systemic administration of uric acid, 1,000 mg, in healthy volunteers, compared with vitamin C, 1,000 mg. We observed a significant increase in serum free-radical scavenging capacity from baseline during uric acid and vitamin C infusion, using two methodologically distinct antioxidant assays. The effect of uric acid was substantially greater than that of vitamin C.
Authors:
W S Waring; D J Webb; S R Maxwell
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  38     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-07     Completed Date:  2001-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology Unit and Research Centre, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK. s.waring@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / administration & dosage*,  pharmacology
Ascorbic Acid / administration & dosage,  pharmacology
Creatinine / blood
Double-Blind Method
Female
Free Radical Scavengers / administration & dosage,  blood*,  pharmacology
Humans
Male
Oxidative Stress*
Placebos
Uric Acid / administration & dosage*,  blood*,  pharmacology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Placebos; 50-81-7/Ascorbic Acid; 60-27-5/Creatinine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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