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Systemic treatment of locally-advanced, nonmetastatic cutaneous squamous cell carcinoma: a review of the literature.
MedLine Citation:
PMID:  21777215     Owner:  NLM     Status:  Publisher    
Background:  There is a small subset of locally advanced nonmetastatic cutaneous squamous cell carcinoma for which local therapy is not curative or feasible, making systemic therapy a possible treatment option. Objectives:  To calculate overall response rates, median time to response and median duration of response, of locally advanced nonmetastatic cutaneous squamous cell carcinoma to systemic therapy (targeted agents, biologic response modifiers, and chemotherapy). Methods:  Medline and Pubmed were searched for reports of nonmetastatic locally advanced cutaneous squamous cell carcinoma treated with systemic therapy from 1970 to 2011. No limits were placed on study design. Overall response rates, time to response, and duration of response were calculated for systemic therapy overall and for each treatment category. Results:  Twenty-eight observational studies yielded 119 patients for analysis. The overall response rate for systemic therapy was 72% (time to response 9 weeks, duration of response 42 weeks). Targeted therapy and biologic response modifiers achieved overall response rates of 100% (time to response 12 weeks, duration of response 20 weeks) and 86% (time to response 10 weeks, duration of response 20 weeks), respectively, and oral chemotherapy, intravenous chemotherapy, and intra-arterial chemotherapy achieved response rates of 20% (time to response 10 weeks, duration of response 24 weeks), 66% (time to response 3 weeks, duration of response 44 weeks), and 100% (time to response 15 weeks, duration of response 112 weeks), respectively. Limitations:  No controlled data was identified and sample sizes were small. Conclusions:  Systemic treatment leads to objective responses in locally advanced cutaneous squamous cell carcinoma that are not amenable to local cure.
R Behshad; J Garcia-Zuazaga; J S Bordeaux
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio, USA Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
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