| Systemic treatment of AIDS-related Kaposi sarcoma: current status and perspectives. | |
| | |
MedLine Citation:
|
PMID: 16860939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Kaposi's sarcoma (KS) is the most frequent type of cancer in patients with Acquired Immune Deficiency Syndrome (AIDS). In the western world, its incidence decreased dramatically in the era of highly active anti-retroviral therapy (HAART). In contrast, the incidence of KS has been steadily climbing in parallel with the AIDS epidemic in Africa over the past 10-15 years, being the most common cancer in adult men in countries like Uganda and Zimbabwe. AIDS-KS can be diagnosed at any stage of HIV infection, although it more commonly occurs in the setting of severe immune suppression, especially with an elevated viral load. Up to now, AIDS-KS is still an incurable disease. Its clinical course is variable, ranging from very indolent cases, requiring no or minimal therapy, to a rapidly progressive disease. Various local therapies are available to control small and asymptomatic lesions, while cytotoxic, immunological and biological therapies can be considered for more aggressive disease. The primary goal of therapy in most of the cases is to provide safe and effective palliation, in order to quality of life. Optimal anti-retroviral therapy is a key component of AIDS-KS management. There are still many questions to be answered in the management of patients with AIDS-KS, such as (1) What are the therapeutic agents that should be used in this disease, and in which sequence? and (2) What are the benefits and risks expected with each treatment option? The aim of this review is to discuss the systemic management of AIDS-KS, with special focus on the above mentioned questions. |
| | |
Authors:
|
Tazio Vanni; Eduardo Sprinz; Marcelo Warlet Machado; Rodrigo de C Santana; Benedito Antonio L Fonseca; Gilberto Schwartsmann |
Related Documents
:
|
2205469 - Otologic disease in the acquired immunodeficiency syndrome. 1693429 - Aids kaposi sarcoma-derived cells produce and respond to interleukin 6. 1549809 - Bilateral angle-closure glaucoma associated with uveal effusion: presenting sign of hiv... 3578259 - Porphyria cutanea tarda associated with the acquired immune deficiency syndrome. 4061379 - Pulmonary irradiation for kaposi's sarcoma in aids. 1998759 - Changing disease patterns in patients with aids in a referral centre in the united king... 18613549 - Household and community transmission of the asian influenza a (h2n2) and influenza b vi... 11297119 - Confidentiality. 22023569 - Everyday problem solving across the adult life span: solution diversity and efficacy. |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-07-24 |
Journal Detail:
|
Title: Cancer treatment reviews Volume: 32 ISSN: 0305-7372 ISO Abbreviation: Cancer Treat. Rev. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-08 Completed Date: 2006-11-14 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7502030 Medline TA: Cancer Treat Rev Country: England |
Other Details:
|
Languages: eng Pagination: 445-55 Citation Subset: IM |
Affiliation:
|
Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
complications*,
drug therapy Adult Anthracyclines / administration & dosage Antineoplastic Combined Chemotherapy Protocols Antiretroviral Therapy, Highly Active Antiviral Agents / therapeutic use Clinical Trials as Topic Humans Interferons / therapeutic use Liposomes Male Paclitaxel / administration & dosage Sarcoma, Kaposi / drug therapy*, epidemiology, virology* |
| Chemical | |
Reg. No./Substance:
|
0/Anthracyclines; 0/Antiviral Agents; 0/Liposomes; 33069-62-4/Paclitaxel; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primary bone osteosarcoma in the pediatric age: state of the art.
Next Document: Heavy drinking across the transition to college: predicting first-semester heavy drinking from preco...