Document Detail

Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.
MedLine Citation:
PMID:  11524350     Owner:  NLM     Status:  MEDLINE    
We compared the systemic toxicity of bupivacaine, levobupivacaine, and ropivacaine in anesthetized rats. We also compared the ability to resuscitate rats after lethal doses of these local anesthetics. Bupivacaine, levobupivacaine, or ropivacaine was infused at a rate of 2 mg. kg(-1). min(-1) while electrocardiogram, electroencephalogram, and arterial pressure were continuously monitored. When asystole was recorded, drug infusion was stopped and a resuscitation sequence was begun. Epinephrine 0.01 mg/kg was administered at 1-min intervals while external cardiac compressions were applied. Resuscitation was considered successful when a systolic arterial pressure > or =100 mm Hg was achieved within 5 min. The cumulative doses of levobupivacaine and ropivacaine that produced seizures were similar and were larger than those of bupivacaine. The cumulative doses of levobupivacaine that produced dysrhythmias and asystole were smaller than the corresponding doses of ropivacaine, but they were larger than those of bupivacaine. The number of successful resuscitations did not differ among groups. However, a smaller dose of epinephrine was required in the Ropivacaine group than in the other groups. We conclude that the systemic toxicity of levobupivacaine is intermediate between that of ropivacaine and bupivacaine when administered at the same rate and that ropivacaine-induced cardiac arrest appears to be more susceptible to treatment than that induced by bupivacaine or levobupivacaine.
S Ohmura; M Kawada; T Ohta; K Yamamoto; T Kobayashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  93     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-28     Completed Date:  2001-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-8     Citation Subset:  AIM; IM    
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Amides / administration & dosage,  toxicity*
Anesthetics, Local / administration & dosage,  toxicity*
Arrhythmias, Cardiac / chemically induced
Blood Gas Analysis
Blood Pressure / drug effects
Bupivacaine / administration & dosage,  toxicity*
Cardiovascular Diseases / chemically induced
Central Nervous System Diseases / chemically induced
Heart Rate / drug effects
Infusions, Intravenous
Norepinephrine / pharmacology
Rats, Sprague-Dawley
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Amides; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 51-41-2/Norepinephrine; 84057-95-4/ropivacaine
Comment In:
Anesthesiology. 2004 Aug;101(2):552-3   [PMID:  15277947 ]
Anesth Analg. 2002 Feb;94(2):479-80   [PMID:  11812729 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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