Document Detail

Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation.
MedLine Citation:
PMID:  12643419     Owner:  NLM     Status:  MEDLINE    
We present the case of a newborn male with D-transposition of the great arteries, ventricular septal defect, and subpulmonary stenosis who experienced two episodes of systemic-to-pulmonary artery shunt thrombosis. Hematologic evaluation revealed heterozygous factor V Leiden mutation. This report emphasizes the importance of evaluation for inherited coagulation disorders in pediatric patients with unexpected thrombotic complications.
Janet M Simsic; Walter E Uber; John Lazarchick; Scott M Bradley
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  74     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2003-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2179-81     Citation Subset:  AIM; IM    
Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
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MeSH Terms
Anastomosis, Surgical
Blood Coagulation Disorders, Inherited / genetics
Factor V / genetics*
Heart Defects, Congenital / complications,  surgery
Infant, Newborn
Pulmonary Artery / surgery*
Thrombosis / etiology*
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V
Comment In:
Ann Thorac Surg. 2004 Jun;77(6):2260-1   [PMID:  15172327 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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