Document Detail

Systemic theophylline augments the blood oxygen level-dependent response to forepaw stimulation in rats.
MedLine Citation:
PMID:  11950649     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Functional MR imaging with blood oxygen level-dependent (BOLD) contrast enhancement is believed to rely on changes in cerebral blood flow and deoxyhemoglobin level to estimate the location and degree of neural activation. We studied the relationship between neural activation and the observed BOLD response by using theophylline, an antagonist of the inhibitory neurotransmitter adenosine and a potent inhibitor of the vasodilatory response to neural activation. METHODS: Using a rat model with electrical forepaw stimulation, we performed fMRI measurements before and after the systemic injection of either theophylline (0.1 mmol/kg) or an equivalent volume of saline. Changes in the BOLD response were quantified by determining the number of activated voxels and the amplitude of the BOLD response for each animal in the theophylline and saline groups. RESULTS: The theophylline group had a significantly Tincreased BOLD response (70-150% increased activated voxel count and 60-65% increased BOLD response amplitude) at 45 and 60 minutes after systemic injection compared with baseline. The response of the saline-injected control group did not change significantly. CONCLUSION: The administration of systemic theophylline significantly augmented the BOLD response due to either an elevation of resting deoxyhemoglobin levels or the neuroexcitatory effect of theophylline. This effect potentially could be used in human fMRI studies to increase the sensitivity of the BOLD response.
Douglas W Morton; Kenneth R Maravilla; Joseph R Meno; H Richard Winn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  23     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-05-09     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  588-93     Citation Subset:  IM    
Department of Radiology, University of Washington, Seattle 98195, USA.
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MeSH Terms
Adenosine / antagonists & inhibitors
Brain Mapping*
Cerebrovascular Circulation / drug effects*
Electric Stimulation
Forelimb / innervation
Magnetic Resonance Imaging* / methods
Oxygen / blood*
Rats, Sprague-Dawley
Theophylline / pharmacology*
Vasodilation / drug effects
Grant Support
Reg. No./Substance:
58-55-9/Theophylline; 58-61-7/Adenosine; 7782-44-7/Oxygen
Comment In:
AJNR Am J Neuroradiol. 2002 Apr;23(4):507-8   [PMID:  11950635 ]

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