Document Detail


Systemic theophylline augments the blood oxygen level-dependent response to forepaw stimulation in rats.
MedLine Citation:
PMID:  11950649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Functional MR imaging with blood oxygen level-dependent (BOLD) contrast enhancement is believed to rely on changes in cerebral blood flow and deoxyhemoglobin level to estimate the location and degree of neural activation. We studied the relationship between neural activation and the observed BOLD response by using theophylline, an antagonist of the inhibitory neurotransmitter adenosine and a potent inhibitor of the vasodilatory response to neural activation. METHODS: Using a rat model with electrical forepaw stimulation, we performed fMRI measurements before and after the systemic injection of either theophylline (0.1 mmol/kg) or an equivalent volume of saline. Changes in the BOLD response were quantified by determining the number of activated voxels and the amplitude of the BOLD response for each animal in the theophylline and saline groups. RESULTS: The theophylline group had a significantly Tincreased BOLD response (70-150% increased activated voxel count and 60-65% increased BOLD response amplitude) at 45 and 60 minutes after systemic injection compared with baseline. The response of the saline-injected control group did not change significantly. CONCLUSION: The administration of systemic theophylline significantly augmented the BOLD response due to either an elevation of resting deoxyhemoglobin levels or the neuroexcitatory effect of theophylline. This effect potentially could be used in human fMRI studies to increase the sensitivity of the BOLD response.
Authors:
Douglas W Morton; Kenneth R Maravilla; Joseph R Meno; H Richard Winn
Related Documents :
25225109 - Five heavy metallic elements and age-related macular degeneration: korean national hea...
18607429 - Temporal statistical analysis of laser speckle images and its application to retinal bl...
6275909 - Oxygenation dependence of the transverse relaxation time of water protons in whole bloo...
1917389 - Blood-retinal barrier breakdown investigated by real-time magnetic resonance imaging af...
10764089 - Pharmacokinetics of three gadolinium chelates with different molecular sizes shortly af...
3035569 - Deuterium nuclear magnetic resonance measurements of blood flow and tissue perfusion em...
24337429 - Oil-water biphasic parallel flow for the precise patterning of metals and cells.
11173789 - Cerebral blood flow, glucose metabolism and tunel-positive cells in the development of ...
6375409 - Blood leukocyte response in hosts parasitized by the hematophagous arthropods triatoma ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  23     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-05-09     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  588-93     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Washington, Seattle 98195, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine / antagonists & inhibitors
Animals
Brain Mapping*
Cerebrovascular Circulation / drug effects*
Electric Stimulation
Forelimb / innervation
Magnetic Resonance Imaging* / methods
Male
Oxygen / blood*
Rats
Rats, Sprague-Dawley
Theophylline / pharmacology*
Vasodilation / drug effects
Grant Support
ID/Acronym/Agency:
NS21076/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
58-55-9/Theophylline; 58-61-7/Adenosine; 7782-44-7/Oxygen
Comments/Corrections
Comment In:
AJNR Am J Neuroradiol. 2002 Apr;23(4):507-8   [PMID:  11950635 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiographic and embryologic considerations in five cases of middle cerebral artery fenestration.
Next Document:  Relevance of antecedent venography in percutaneous vertebroplasty for the treatment of osteoporotic ...