Document Detail

Systemic side effects associated with the ophthalmic administration of timolol.
MedLine Citation:
PMID:  3882377     Owner:  NLM     Status:  MEDLINE    
Since the introduction of ophthalmic timolol solution in 1978 there have been numerous reports of systemic toxicity associated with its use. The majority of the systemic side effects reported are the same as those associated with oral timolol. Several cases of respiratory distress have been described generally in patients with underlying restrictive airway disease. Cardiovascular effects range from effects on resting pulse rate to the development of overt bradycardia and heart failure. Central nervous system effects reported include fatigue, confusion, depression, and hallucinations. A variety of other systemic effects have also been described. Caution should be used when ophthalmic timolol is administered to elderly patients or those patients with contraindications to systemic beta-blockers.
W P Munroe; J P Rindone; R M Kershner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug intelligence & clinical pharmacy     Volume:  19     ISSN:  0012-6578     ISO Abbreviation:  Drug Intell Clin Pharm     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-04-04     Completed Date:  1985-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0212457     Medline TA:  Drug Intell Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / chemically induced
Central Nervous System Diseases / chemically induced
Lung Diseases / chemically induced
Ophthalmic Solutions / adverse effects*
Skin Diseases / chemically induced
Timolol / administration & dosage,  adverse effects*,  metabolism
Reg. No./Substance:
0/Ophthalmic Solutions; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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