Document Detail

Systemic sclerosis from autoimmunity to alloimmunity.
MedLine Citation:
PMID:  10342891     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The biologic significance of microchimerism from pregnancy in systemic sclerosis and other autoimmune diseases is not fully characterized. METHODS: We based this brief review on a systematic search of the MEDLINE database for all relevant articles published between 1980 and July 1998, indexing systemic sclerosis, microchimerism, and pregnancy as key words. We also searched textbooks, meeting proceedings, and reference lists. RESULTS: Fetal microchimerism and class II human leukocyte antigen (HLA) compatibility between mother and fetus are common among women with systemic sclerosis. Alternative sources of microchimerism include the engraftment of donor cells after a blood transfusion, from a dizygotic twin, or possibly from the mother. CONCLUSIONS: Systemic sclerosis could be a form of chronic graft-versus-host disease caused by fetal or maternal cells, which have crossed the placenta and have remained unrecognized by the host due to class II HLA compatibility.
G Famularo; C De Simone
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  92     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-04     Completed Date:  1999-06-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  472-6     Citation Subset:  AIM; IM    
Department of Emergency Medicine, Ospedale San Camillo, Rome, Italy.
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MeSH Terms
Autoimmune Diseases / immunology*
Fetus / immunology
Histocompatibility Antigens Class II / immunology
Isoantigens / immunology
Pregnancy Complications / immunology
Scleroderma, Systemic / immunology*
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 0/Isoantigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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