Document Detail

Systemic sclerosis - continuing progress in developing clinical measures of response.
MedLine Citation:
PMID:  17477486     Owner:  NLM     Status:  MEDLINE    
Few randomized controlled trials (RCT) have shown a demonstrable treatment effect in systemic sclerosis (SSc), making it difficult to evaluate outcome measures in this disease indication. Results from recent RCT, including those evaluating cyclophosphamide for SSc interstitial lung disease and endothelin receptor antagonists for pulmonary hypertension, have allowed analysis of certain organ-specific endpoints using the OMERACT filter. An earlier metaanalysis established that skin score, measures of Raynaud's, pulmonary function tests, blood pressure, pain, Health Assessment Questionnaire, and Medical Outcomes Survey Short-Form 36 are validated outcome measures in SSc. At OMERACT 8, data regarding validation of high-resolution computed tomography of the lungs, 6-minute walk test, and patient reported outcomes in SSc were presented. A Delphi exercise to develop consensus regarding a combined set of noninvasive measures for pulmonary arterial hypertension (PAH) is under way. Given the protean nature of this illness and its multiorgan system involvement, a composite responder index may be preferable. Another Delphi exercise is designed to develop consensus regarding a combined SSc response index to be validated in future RCT.
Daniel Furst; Dinesh Khanna; Marco Matucci-Cerinic; Philip Clements; Virginia Steen; Janet Pope; Peter Merkel; Ivan Foeldvari; James Seibold; David Pittrow; Richard Polisson; Vibeke Strand
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  34     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-06-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1194-200     Citation Subset:  IM    
University of California at Los Angeles, Los Angeles, California 90025, USA.
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MeSH Terms
Delphi Technique
Endpoint Determination / methods*
Health Status
Meta-Analysis as Topic
Outcome Assessment (Health Care)*
Randomized Controlled Trials as Topic
Scleroderma, Systemic / diagnosis*,  physiopathology,  therapy*
Severity of Illness Index
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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