| Systemic sclerosis complicated with nephrotic syndrome: relevance with antiribosomal P antibody. | |
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MedLine Citation:
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PMID: 11678302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nephrotic syndrome is an extremely rare occurrence in systemic sclerosis (SSc). Here we describe a 39-year-old woman with SSc who developed the nephrotic syndrome along with the expression of antiribosomal P antibody but not of anti-double-stranded DNA antibody in her serum. Although a renal biopsy specimen showed minimal changes on light microscopy, immunofluorescence studies showed granular deposition of C3 and IgM in the glomeruli. The patient recovered from the nephrotic syndrome with the decrease in serum antiribosomal P antibody after the daily administration of 60 mg of prednisolone. It is strongly suggested that antiribosomal P antibody might have been involved in the development of the nephrotic syndrome in our patient. |
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Authors:
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S Hirohata; T Ohse; A Takeuchi; T Hashimoto |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Rheumatology international Volume: 21 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-25 Completed Date: 2002-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 40-3 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan. shunsei@med.teikyo-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anti-Inflammatory Agents / administration & dosage, therapeutic use Autoantibodies / blood* Autoantigens / immunology Complement C3 / analysis Female Fluorescent Antibody Technique Humans Immunoglobulin M / analysis Kidney Glomerulus / chemistry, ultrastructure Microscopy, Electron Nephrotic Syndrome / etiology*, immunology, pathology Prednisolone / administration & dosage, therapeutic use Protozoan Proteins* Ribosomal Proteins / immunology*, isolation & purification Scleroderma, Systemic / complications*, immunology, pathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Autoantibodies; 0/Autoantigens; 0/Complement C3; 0/Immunoglobulin M; 0/L12E protein, Trypanosoma cruzi; 0/Protozoan Proteins; 0/Ribosomal Proteins; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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