| Systemic sclerosis associated with generalized vasculitis and hypopituitarism. | |
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MedLine Citation:
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PMID: 18437387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic sclerosis (SSc) is a progressively evolving multisystemic disorder of unknown etiology. Beyond skin, several other organs can also be affected with a severity of involvement that is often heterogeneous. We describe a 53-year-old female patient who was admitted urgently to the hospital almost collapsed, because of numerous bleeding deep skin ulcers, located all over the body. Clinical findings and autoantibody screening were typical of SSc. Moreover, both histopathology and immunofluorescence findings were compatible with scleroderma and vasculitis as well. In addition, pituitary hormone investigation revealed severely damaged function of the gland. We assume that severe skin ulceration and serious hypopituitarism were both implications of underlying SSc-associated vasculitis. To the best of our knowledge, these peculiar clinical manifestations have not been described in the international literature to date. |
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Authors:
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John C Katsantonis; John Protopsaltis; Stelios Kokkoris; Paris Brestas; Kyriaki Aroni; Symeon Tournis; Gregory Giannoulis |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-04-24 |
Journal Detail:
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Title: Rheumatology international Volume: 28 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 1165-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, 'Tzanio' General Hospital, Tzani 1, 185 36 Piraeus, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Female Humans Hypopituitarism / complications* Hypothyroidism / complications Middle Aged Prednisolone / therapeutic use Scleroderma, Systemic / complications*, drug therapy, pathology Skin Ulcer / drug therapy Vasculitis / complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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