Document Detail

Systemic sclerosis associated with generalized vasculitis and hypopituitarism.
MedLine Citation:
PMID:  18437387     Owner:  NLM     Status:  MEDLINE    
Systemic sclerosis (SSc) is a progressively evolving multisystemic disorder of unknown etiology. Beyond skin, several other organs can also be affected with a severity of involvement that is often heterogeneous. We describe a 53-year-old female patient who was admitted urgently to the hospital almost collapsed, because of numerous bleeding deep skin ulcers, located all over the body. Clinical findings and autoantibody screening were typical of SSc. Moreover, both histopathology and immunofluorescence findings were compatible with scleroderma and vasculitis as well. In addition, pituitary hormone investigation revealed severely damaged function of the gland. We assume that severe skin ulceration and serious hypopituitarism were both implications of underlying SSc-associated vasculitis. To the best of our knowledge, these peculiar clinical manifestations have not been described in the international literature to date.
John C Katsantonis; John Protopsaltis; Stelios Kokkoris; Paris Brestas; Kyriaki Aroni; Symeon Tournis; Gregory Giannoulis
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-24
Journal Detail:
Title:  Rheumatology international     Volume:  28     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-12     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1165-8     Citation Subset:  IM    
Department of Dermatology, 'Tzanio' General Hospital, Tzani 1, 185 36 Piraeus, Greece.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Hypopituitarism / complications*
Hypothyroidism / complications
Middle Aged
Prednisolone / therapeutic use
Scleroderma, Systemic / complications*,  drug therapy,  pathology
Skin Ulcer / drug therapy
Vasculitis / complications*,  drug therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-24-8/Prednisolone

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