| Systemic sclerosis-associated interstitial pneumonia: evaluation of pulmonary function over a five-year period. | |
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MedLine Citation:
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PMID: 21537649 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate alterations in pulmonary function in patients with systemic sclerosis-associated interstitial pneumonia over a five-year period. METHODS: This was a longitudinal study involving 35 nonsmoking patients with systemic sclerosis and without a history of lung disease. At the first evaluation, performed at the time of the diagnosis of interstitial pneumonia, the patients were submitted to HRCT, spirometry, and measurement of DLCO. The patients were subdivided into two groups by the presence or absence of honeycombing on the HRCT scans. Approximately five years after the first evaluation, the patients were submitted to spirometry and measurement of DLCO only. RESULTS: Of the 35 patients, 34 were women. The mean age was 47.6 years. The mean time between the two evaluations was 60.9 months. Honeycombing was detected on the HRCT scans in 17 patients. In the sample as a whole, five years after the diagnosis, FVC, FEV1 and DLCO significantly decreased (81.3 ± 18.2% vs. 72.1 ± 22.2%; 79.9 ± 17.8% vs. 72.5 ± 20.6%; and 74.0 ± 20.5% vs. 60.7 ± 26.8%, respectively; p = 0.0001 for all), and the FEV1/FVC ratio significantly increased (98.5 ± 7.2% vs. 101.9 ± 7.8%; p = 0.008). In the same period, FVC, FEV1, and DLCO values were significantly lower in the patients with honeycombing on the HRCT scans than in those without (p = 0.0001). CONCLUSIONS: In systemic sclerosis-associated interstitial lung disease, the detection of honeycombing on HRCT is crucial to predicting accelerated worsening of pulmonary function. |
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Authors:
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Agnaldo José Lopes; Domenico Capone; Roberto Mogami; Sara Lucia Silveira de Menezes; Fernando Silva Guimarães; Roger Abramino Levy |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia Volume: 37 ISSN: 1806-3756 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222274 Medline TA: J Bras Pneumol Country: - |
Other Details:
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Languages: ENG; POR Pagination: 144-151 Citation Subset: - |
Affiliation:
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Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro. |
Vernacular Title:
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Pneumonia intersticial associada à esclerose sistêmica: avaliação da função pulmonar no período de cinco anos. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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