Document Detail

Systemic sclerosis-associated interstitial pneumonia: evaluation of pulmonary function over a five-year period.
MedLine Citation:
PMID:  21537649     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate alterations in pulmonary function in patients with systemic sclerosis-associated interstitial pneumonia over a five-year period.
METHODS: This was a longitudinal study involving 35 nonsmoking patients with systemic sclerosis and without a history of lung disease. At the first evaluation, performed at the time of the diagnosis of interstitial pneumonia, the patients were submitted to HRCT, spirometry, and measurement of DLCO. The patients were subdivided into two groups by the presence or absence of honeycombing on the HRCT scans. Approximately five years after the first evaluation, the patients were submitted to spirometry and measurement of DLCO only.
RESULTS: Of the 35 patients, 34 were women. The mean age was 47.6 years. The mean time between the two evaluations was 60.9 months. Honeycombing was detected on the HRCT scans in 17 patients. In the sample as a whole, five years after the diagnosis, FVC, FEV₁ and DLCO significantly decreased (81.3 ± 18.2% vs. 72.1 ± 22.2%; 79.9 ± 17.8% vs. 72.5 ± 20.6%; and 74.0 ± 20.5% vs. 60.7 ± 26.8%, respectively; p = 0.0001 for all), and the FEV₁/FVC ratio significantly increased (98.5 ± 7.2% vs. 101.9 ± 7.8%; p = 0.008). In the same period, FVC, FEV₁, and DLCO values were significantly lower in the patients with honeycombing on the HRCT scans than in those without (p = 0.0001).
CONCLUSIONS: In systemic sclerosis-associated interstitial lung disease, the detection of honeycombing on HRCT is crucial to predicting accelerated worsening of pulmonary function.
Agnaldo José Lopes; Domenico Capone; Roberto Mogami; Sara Lucia Silveira de Menezes; Fernando Silva Guimarães; Roger Abramino Levy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia     Volume:  37     ISSN:  1806-3756     ISO Abbreviation:  J Bras Pneumol     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-05-03     Completed Date:  2011-12-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  101222274     Medline TA:  J Bras Pneumol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  144-51     Citation Subset:  IM    
Rio de Janeiro State University, Rio de Janeiro, Brazil.
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MeSH Terms
Forced Expiratory Volume
Longitudinal Studies
Lung Diseases, Interstitial / etiology,  physiopathology*,  radiography
Middle Aged
Scleroderma, Systemic / complications,  physiopathology*,  radiography
Time Factors
Tomography, X-Ray Computed
Vital Capacity
Comment In:
J Bras Pneumol. 2011 Mar-Apr;37(2):142-3   [PMID:  21537648 ]

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