Document Detail

Systemic responses in patients with intermittent claudication after treadmill exercise.
MedLine Citation:
PMID:  7827927     Owner:  NLM     Status:  MEDLINE    
The effect of 5 min treadmill exercise was investigated in claudicant patients and healthy controls; systemic neutrophil count, plasma thromboxane and von Willebrand's factor (a marker for endothelial injury) were measured. Median (interquartile range (i.q.r.)) resting neutrophil count was 5.6 (5.2-6.0) x 10(6) cells l-1 in claudicants and 2.8 (2.6-3.2) x 10(6) l-1 in controls (P < 0.05); this increased in those with claudication to 7.1 (6.2-7.7) x 10(6) l-1 immediately after exercise (P < 0.05). The resting plasma thromboxane level was 32.1 (25.0-60.0) pg ml-1 in claudicants and rose to 135.0 (104.0-141.3) pg ml-1 15 min after exercise, compared with a rise from 25.0 (22.0-33.5) to 55.5 (33.0-67.0) pg ml-1 in controls (P < 0.05). The resting serum von Willebrand's factor level was 127 (110-135) units dl-1 in claudicants compared with 60 (48-71) units dl-1 in controls; this difference persisted after exercise (P < 0.01). In patients with claudication, the level of von Willebrand's factor increased to 150 (140-156) units dl-1 60 min after exercise (P < 0.05). Free radical scavenging capacity was also investigated by measuring the plasma antioxidant activity of glutathione peroxidase and its essential non-metal cofactor selenium. Scavenging capacity was lower in claudicant patients whose median (i.q.r.) glutathione peroxidase activity (change in absorbance per min per ml plasma) was 2.84 (2.39-3.61) versus 3.24 (3.06-3.79) in controls (P < 0.05). Similarly, plasma concentrations of selenium were lower in claudicants at a median (i.q.r.) of 75.0 (58.0-81.0) micrograms l-1 compared with 88.0 (75.0-92.5) micrograms l-1 in controls (P < 0.05). Exercise in claudicant patients leads to neutrophilia and thromboxane production with subsequent endothelial injury. The antioxidant activity of glutathione peroxidase is reduced in patients with claudication and may allow the unopposed action of free radicals to damage endothelium.
A T Edwards; A D Blann; V J Suarez-Mendez; A M Lardi; C N McCollum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  81     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1738-41     Citation Subset:  AIM; IM    
University Department of Surgery, University Hospital of South Manchester, UK.
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MeSH Terms
Exercise Test
Glutathione Peroxidase / metabolism
Intermittent Claudication / blood*
Leukocyte Count
Middle Aged
Neutrophil Activation / physiology*
Physical Exertion / physiology*
Platelet Activation / physiology*
Thromboxane B2 / blood
von Willebrand Factor / metabolism
Reg. No./Substance:
0/von Willebrand Factor; 54397-85-2/Thromboxane B2; EC Peroxidase
Comment In:
Br J Surg. 1995 Jun;82(6):856-7   [PMID:  7627538 ]

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