Document Detail


Systemic responses after bronchial aspirin challenge in sensitive patients with asthma.
MedLine Citation:
PMID:  18086495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In aspirin-sensitive patients with asthma, bronchial obstruction induced by oral aspirin may be associated with extrabronchial symptoms, suggesting the systemic character of the response. OBJECTIVE: Go assess potential systemic effects of local aspirin challenge, hemopoietic progenitors were measured in the peripheral blood of challenged patients. METHODS: In 19 patients with a history of aspirin-induced asthma, placebo-controlled bronchial challenges with lysine-aspirin were performed. Peripheral blood was collected before and then 1 hour and 20 hours after challenge (placebo or aspirin). Using the flow-cytometric method, the numbers of leukocyte (CD34+ cells) and eosinophil (CD34+CD125+ cells) progenitors were determined. RESULTS: The challenge was positive in 13 patients; 6 patients had isolated local bronchial reaction, and 7 patients developed systemic symptoms (bronchial and extrabronchial). In patients with positive challenge (n = 13), leukocyte progenitors increased significantly at 1 hour and 20 hours after challenge (mean, 0.04% at baseline, 0.066% at 1 hour after challenge, and 0.073% at 20 hours; P < .05). Eosinophil progenitors raised significantly from mean 0.017% before challenge to 0.04% (P < .05) at 20 hours after the challenge. At 20 hours after the challenge, the increase in leukocyte and eosinophil progenitors was observed only in patients with systemic reactions. Positive aspirin challenge was associated with a significant increase in eotaxin 2 serum concentration. CONCLUSION: This study demonstrated that bronchial challenge with aspirin may involve systemic reactions and is associated with mobilization of leukocyte and eosinophil progenitor cells from the bone marrow.
Authors:
Joanna S Makowska; Janina Grzegorczyk; Barbara Bienkiewicz; Maria Wozniak; Marek L Kowalski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-20
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  121     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-13     Completed Date:  2008-03-19     Revised Date:  2008-08-29    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Aspirin / administration & dosage,  adverse effects,  analogs & derivatives,  diagnostic use*
Asthma / blood,  complications,  pathology,  physiopathology*
Bone Marrow Cells / pathology
Bronchi / physiopathology
Chemokine CCL24 / blood
Chemokines / blood
Cytokines / blood
Drug Hypersensitivity / complications
Eosinophils / pathology
Female
Forced Expiratory Volume / drug effects
Humans
Leukocyte Count
Leukocytes / pathology
Lysine / administration & dosage,  analogs & derivatives,  diagnostic use
Male
Middle Aged
Single-Blind Method
Stem Cells / pathology
Up-Regulation
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Chemokine CCL24; 0/Chemokines; 0/Cytokines; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 56-87-1/Lysine
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2008 Jul;122(1):214-5; author reply 215   [PMID:  18468673 ]
J Allergy Clin Immunol. 2008 Aug;122(2):430-1   [PMID:  18586317 ]

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