Document Detail

Systemic and renal effects of enalapril and its effects on cardiac mass.
MedLine Citation:
PMID:  6100878     Owner:  NLM     Status:  MEDLINE    
Enalapril is a new angiotensin converting enzyme (ACE) inhibitor and has been shown to be of benefit in the treatment of both renovascular and essential hypertension. We have studied the systemic and renal haemodynamic, biochemical and cardiac adaptive changes induced by this agent in eight patients with essential hypertension before and after 12 weeks of therapy. Mean arterial pressure fell from 110 to 90 mmHg (P less than 0.01) and this was mediated through a fall in total peripheral resistance, cardiac index and heart rate remaining unchanged. Renal plasma flow rose in six patients. Renal vascular resistance fell in all patients (P less than 0.01). Left ventricular mass index was reduced from a mean of 166 +/- 29 to 117 +/- 8 g/m2 (P less than 0.05) and systolic ventricular function remained unchanged. Thus, enalapril lowers arterial pressure by reducing total peripheral resistance, has favourable haemodynamic effects on the kidney, and produces a reduction in left ventricular mass within three months of the start of therapy.
F G Dunn; W Oigman; H O Ventura; F H Messerli; I Kobrin; E D Frohlich
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  2     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S57-61     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure / drug effects
Clinical Trials as Topic
Enalapril / therapeutic use*
Heart / drug effects*
Hemodynamics / drug effects*
Hypertension / drug therapy*,  physiopathology
Kidney / drug effects*,  physiopathology
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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