Document Detail

Systemic and regional haemodynamics in anterior hypothalamic hypertension in spontaneously hypertensive and Wistar-Kyoto rats.
MedLine Citation:
PMID:  7449264     Owner:  NLM     Status:  MEDLINE    
1. Systemic and regional haemodynamics were determined in conscious Wistar-Kyoto and spontaneously hypertensive rats with the radioactive microsphere technique after sham lesion or bilateral electrolytic lesion of the nuclei of the anterior hypothalamus. 2. Anterior hypothalamic lesions produced an increase in blood pressure, heart rate and cardiac output. 3. In the rats with lesions there were changes in regional haemodynamics: heart and skeletal muscle flow increased; renal, skin ans splanchnic flow decreased. 4. The haemodynamic consequences of ablation of the anterior hypothalamus were similar in both normotensive Wistar-Kyoto and spontaneously hypertensive rats. The haemodynamic pattern resembles that seen during fighting and exercise.
D H Suarez; B L Pegram; E D Frohlich
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  59 Suppl 6     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  251s-253s     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Heart Rate
Hypertension / physiopathology*
Hypothalamus / physiopathology*
Hypothalamus, Anterior / physiopathology*
Regional Blood Flow
Vascular Resistance
Grant Support

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