Document Detail


Systemic, pulmonary and renal haemodynamic and renal morphologic effects of intravenously infused iodixanol. A study in the pig of a new iso-osmolar contrast medium.
MedLine Citation:
PMID:  2261302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The systemic, pulmonary and renal haemodynamic effects following an intravenous infusion (1 ml/s, 4 ml/kg) of a non-ionic isoosmolar contrast medium (iodixanol) were investigated in 8 pigs. Histopathologic changes occurring after infusion of iodixanol were studied by repeated renal biopsies. Iodixanol caused a significant increase of cardiac output, mean right atrial pressure, mean pulmonary arterial pressure, mean pulmonary arterial occlusion pressure and mean arterial pressure. There was a decrease of the systemic and pulmonary vascular resistances. Most renal biopsies showed no pathologic findings after infusion of iodixanol but in 3 specimens proteinaceous content was observed 15 min after infusion.
Authors:
O Sunnegårdh; S O Hietala; E Holtz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  31     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-02-05     Completed Date:  1991-02-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Radiology, University Hospital of Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Female
Hemodynamics / drug effects*
Kidney / blood supply,  drug effects*
Lung / drug effects*
Osmolar Concentration
Pulmonary Artery / physiology
Swine
Triiodobenzoic Acids / administration & dosage,  chemistry,  pharmacology*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Triiodobenzoic Acids; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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