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Systemic protein therapy for recessive dystrophic epidermolysis bullosa: how far are we from clinical translation?
MedLine Citation:
PMID:  23760051     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this issue, Woodley et al. report restoration of anchoring fibril formation and dermal-epidermal adherence in a murine model of recessive dystrophic epidermolysis bullosa (RDEB) by intravenous injection of recombinant human type VII collagen. This work follows a previous report by the same group of the surprising capability of intradermally injected type VII collagen protein to reverse RDEB, and it opens new therapeutic avenues.
Authors:
Alain Hovnanian
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  133     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1719-21     Citation Subset:  IM    
Affiliation:
1] University Paris Descartes Sorbonne Paris Cité, Imagine Institute, Paris, France [2] INSERM U781, Paris, France [3] Department of Genetics, Necker Hospital, Paris, France.
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