Document Detail

Systemic piroxicam as an adjunct to patient-controlled analgesia with alfentanil for postoperative pain relief.
MedLine Citation:
PMID:  8758159     Owner:  NLM     Status:  MEDLINE    
In a double-blind, placebo-controlled study, the non-steroidal anti-inflammatory drug, piroxicam, in combination with alfentanil given in a patient-controlled analgesia system, was compared with alfentanil alone given by the same route for analgesic effect, side effects and acute phase reaction over a 4-day period following anterior cruciate ligament reconstruction of the knee. The patients receiving piroxicam had lower pain scores and consumed less alfentanil. There were no differences with regard to side effects between the two treatment groups, apart from significantly more sedation at 08.00 h on the first postoperative day in the non-piroxicam group. Piroxicam did not influence either the levels of interleukin-6 or the acute phase response to surgery.
P Van Lancker; J Devulder; G Rolly
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  51     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-10-08     Completed Date:  1996-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  658-62     Citation Subset:  AIM; IM    
Department of Anaesthesia, University Hospital, Gent, Belgium.
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MeSH Terms
Alfentanil / administration & dosage
Analgesia, Patient-Controlled*
Analgesics, Opioid / administration & dosage
Anterior Cruciate Ligament / surgery
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
C-Reactive Protein / metabolism
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Interleukin-6 / blood
Orosomucoid / metabolism
Oxygen / blood
Pain, Postoperative / drug therapy*
Piroxicam / administration & dosage*
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Interleukin-6; 0/Orosomucoid; 36322-90-4/Piroxicam; 71195-58-9/Alfentanil; 7782-44-7/Oxygen; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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