| Systemic piroxicam as an adjunct to patient-controlled analgesia with alfentanil for postoperative pain relief. | |
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MedLine Citation:
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PMID: 8758159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind, placebo-controlled study, the non-steroidal anti-inflammatory drug, piroxicam, in combination with alfentanil given in a patient-controlled analgesia system, was compared with alfentanil alone given by the same route for analgesic effect, side effects and acute phase reaction over a 4-day period following anterior cruciate ligament reconstruction of the knee. The patients receiving piroxicam had lower pain scores and consumed less alfentanil. There were no differences with regard to side effects between the two treatment groups, apart from significantly more sedation at 08.00 h on the first postoperative day in the non-piroxicam group. Piroxicam did not influence either the levels of interleukin-6 or the acute phase response to surgery. |
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Authors:
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P Van Lancker; J Devulder; G Rolly |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 51 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-10-08 Completed Date: 1996-10-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 658-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, University Hospital, Gent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alfentanil / administration & dosage Analgesia, Patient-Controlled* Analgesics, Opioid / administration & dosage Anterior Cruciate Ligament / surgery Anti-Inflammatory Agents, Non-Steroidal / administration & dosage* C-Reactive Protein / metabolism Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Female Humans Interleukin-6 / blood Male Orosomucoid / metabolism Oxygen / blood Pain, Postoperative / drug therapy* Piroxicam / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Interleukin-6; 0/Orosomucoid; 36322-90-4/Piroxicam; 71195-58-9/Alfentanil; 7782-44-7/Oxygen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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