Document Detail


Systemic morphofunctional assessment of ultrastructural organization and pathology of myocardial cells.
MedLine Citation:
PMID:  2737417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A quantitative multifactorial method based on stereological parameters of ultrastructure has been worked out for unambiguous assessment of the condition of myocardial cells. The contraction force (F) generated by 1mm3 of myocardial cell mass, being the essential function of myocardial cells, had been chosen as a system-forming factor. Index F is calculated by our equation, as follows: F = K x Vvmf x (1/Svcr, 1/2.3Svmt, Vvspl/226.1, 1/2.3Svmf, Vv.mf/1533.7) x f x v1, where K describes the measure of dissocation of myofilaments and where the product of f x v1 is a constant. The data regarding the function of myocardial cell contractility measured by direct micromechanography were quantitatively parallel to those recordable by the new method, with one and the same animal being involved. Hence, evidence has been produced to the value of the new method in terms of objectivity and functional equivalence. This method can be used for quantitative testing for diagnosis and prognostication in theoretical and applied cardiology and in cardiac surgery.
Authors:
T A Gevondyan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gegenbaurs morphologisches Jahrbuch     Volume:  135     ISSN:  0016-5840     ISO Abbreviation:  Gegenbaurs Morphol Jahrb     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-02     Completed Date:  1989-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370733     Medline TA:  Gegenbaurs Morphol Jahrb     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  195-7     Citation Subset:  IM    
Affiliation:
Central Research Laboratory Institute of Advanced Medical Training, Yerevan, USSR.
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MeSH Terms
Descriptor/Qualifier:
Animals
Male
Mathematics
Myocardium / pathology,  ultrastructure*
Rats

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