| Systemic microsporidiosis and toxoplasmosis in a patient with T prolymphocytic leukemia | |
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MedLine Citation:
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PMID: 19046839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of microsporidiosis in a 72-year-old woman presenting with prolymphocytic leukemia. The underlying conditions 7 months after leukemia was diagnosed were pancytopenia and immunosuppression due to alemtuzumab and pentostatin. The patient's status had worsened and she presented with dysuria. Urine cultures for bacteria were repeatedly negative. She was first empirically treated with broad-spectrum antibiotics. Three months later, urinary symptoms were persisting. Her blood lymphocyte count was 90/microl. Urine examination was positive for microsporidia using modified trichrome staining and Uvitex 2B fluorescence. Microsporidia were also detected in stools. The patient was cured by albendazole. This was consistent with an infection due to Encephalitozoon sp. Concurrently, disseminated toxoplasmosis was diagnosed. Toxoplasma gondii was detected in bone marrow, broncho-alveolar lavage and cerebrospinal fluid. She was successfully treated with sulfadiazine-pyrimethamine. Four cases of microsporidiosis in myeloid leukemic patients have been already described. The present case in a patient with lymphoid leukemia is the first to be reported. |
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Authors:
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D Jamet; D Quinio; E Moalic; J-C Ianotto; F Dalbies; G Guillerm; V Marion; C Berthou; G Nevez |
Publication Detail:
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Type: Case Reports; English Abstract; Journal Article Date: 2008-11-28 |
Journal Detail:
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Title: Médecine et maladies infectieuses Volume: 39 ISSN: 0399-077X ISO Abbreviation: Med Mal Infect Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0311416 Medline TA: Med Mal Infect Country: France |
Other Details:
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Languages: fre Pagination: 406-8 Citation Subset: IM |
Affiliation:
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LUBEM EA 3882, université de Brest, France. deborah.jamet@chu-brest.fr |
Vernacular Title:
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Microsporidiose et toxoplasmose disséminées chez une patiente présentant une leucémie prolymphocytaire T. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Albendazole / therapeutic use Animals Bone Marrow / parasitology Encephalitozoon / isolation & purification Encephalitozoonosis / complications*, drug therapy Feces / microbiology Female Humans Leukemia, Prolymphocytic, T-Cell / complications*, microbiology Toxoplasma / isolation & purification Toxoplasmosis / complications, drug therapy |
| Chemical | |
Reg. No./Substance:
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54965-21-8/Albendazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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