Document Detail

Systemic methotrexate treatment in early unruptured ectopic pregnancy.
MedLine Citation:
PMID:  9478299     Owner:  NLM     Status:  MEDLINE    
Ectopic pregnancy is one of the most common and dangerous complications of the early pregnancy period. Until now diagnosis has been late because major symptoms occur after tubal rupture and so only demolitive surgery has been possible. At present, with the appearance of ultrasound in obstetrics an earlier diagnosis of this pathology can be made before tubal rupture so medical treatment has become possible. We treated a series of twelve patients with early ectopic pregnancy (9 tubal and 3 with no localized site of implantation) with intramuscular 0.5 mg/kg methotrexate and oral 0.1 mg/kg of folic acid (Citrovorum Factor) on alternate days, in the attempt to reduce hospitalization and obtain more effective and safer medical management. We observed a fall in serum beta-HCG levels after one cycle of treatment in 11 out of 12 patients and after two cycles of therapy in the remaining case. Minimal side-effects were observed in four cases. Three pregnancies occurred after treatment before the advised interval time and ended in blighted ovum. Methotrexate systemic therapy can be considered an elective treatment and a sufficiently safe management in early unruptured ectopic pregnancy when a good clinical selection of patients is performed.
F Scarpellini; R Boccadoro; L Scarpellini
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  24     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-13     Completed Date:  1998-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  141-3     Citation Subset:  IM    
II Institute of Ob/Gyn, University of Rome La Sapienze, Italy.
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MeSH Terms
Administration, Oral
Chorionic Gonadotropin / blood,  metabolism
Folic Acid Antagonists / administration & dosage,  therapeutic use*
Methotrexate / administration & dosage,  therapeutic use*
Pregnancy, Ectopic / drug therapy*,  ultrasonography
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Folic Acid Antagonists; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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