Document Detail


Systemic methionine-enkephalin evokes cardiostimulatory responses in the human.
MedLine Citation:
PMID:  3628079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiovascular effects of bolus doses of methionine-enkephalin (Met5-ENK) (1 to 100 micrograms/kg) were studied in 9 subjects in whom, at cardiac catheterization for evaluation of chest pain, patent coronary arteries were found. Met5-ENK produced a simultaneous increase in blood pressure and heart rate beginning within 20 sec, reaching maximal values between 30 and 40 sec, and then terminating by 60 sec. Heart rate, systolic, diastolic, and mean arterial blood pressures increased significantly (p less than 0.0005); pulse pressure remained unchanged. Positive dose-effect relationships were observed for heart rate (p less than 0.002), systolic, diastolic, and mean arterial blood pressures (p less than 0.05). Naloxone (0.5 mg/kg), given to 4 subjects, prevented the heart rate and blood pressure changes associated with Met5-ENK administration, demonstrating that the cardiovascular changes were mediated by opiate receptors. Subjects also described cutaneous paresthesias which were not prevented by naloxone pretreatment. These data suggest a role for peripheral enkephalins in cardiovascular regulation.
Authors:
T D Giles; G E Sander; J C Rice; A C Quiroz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  8     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1987 Jul-Aug
Date Detail:
Created Date:  1987-10-21     Completed Date:  1987-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Diastole / drug effects
Enkephalin, Methionine / pharmacology*
Heart Catheterization
Heart Rate / drug effects*
Humans
Naloxone / pharmacology
Pulse / drug effects*
Systole / drug effects
Chemical
Reg. No./Substance:
465-65-6/Naloxone; 58569-55-4/Enkephalin, Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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